Thymosin Alpha 1
Thymosin a-1 is a major component of Thymosin Fraction 5 and responsible for restoring immune function, particularly cell mediated immune function. Recent studies showed that the Thymosin alpha-1 molecule increased major histocompatibility complex (MHC) class-1 and Toll-like receptor expression as well as cytokine production, suggesting its immunoregulatory role.
The drug is in Phase III trials for the treatment of hepatitis C and in Phase II trials for hepatitis B. Additional possible indications are malignant melanoma, hepatocellular carcinoma, drug-resistant tuberculosis, and Di George’s syndrome as well as any chronic cancer or viral disease. Some physicians are using thymosin for chronic fatigue and Lyme disease as well.
TA1 is thought to modulate the immune system by augmenting T-cell function. TA1 may affect thymocytes by stimulating their differentiation or by converting them to active T cells. TA1 is rapidly absorbed, achieving peak serum concentrations within two hours. Blood levels return to baseline within 24 hours, and the serum half-life is approximately 2 hours.
Thymosin Beta 4
Thymosin is a hormone secreted from the thymus. Its primary function is to stimulate the production of T cells, which are an important part of the immune system. Thymosin also assists in the development of B cells to plasma cells to produce antibodies. The predominant form of thymosin, thymosin b4, is a member of a highly conserved family of actin monomer-sequestering proteins. In addition to its role as a major actin-sequestering molecule, Thymosin-beta4 has a role intissue repair. Tß4 has been found to play an important role in protection, regeneration and remodeling of injured or damaged tissues. The gene for Tß4 has also been found to be one of the first to be unregulated after injuries. Thymosin Beta 4 is currently being trialed as a potential therapy for HIV, AIDS, and Influenza.
Thymulin
Thymulin is a neuroendocrine hormone with immunoregulatory actions. Originally known as ‘serum thymic factor’ (FTS), thymulin binds to a carrier protein and zinc (Zn2+) to exert its biologic properties. Thymulin, albeit an essential hormone for the T lymphocyte differentiation and the normalization of the ratio of T-helper cells to suppressor cells, accumulating evidence suggests its involvement in inflammations of various etiologies. Recently, thymulin has been shown to have anti-nociceptive effects in hyperalgesia and in pain of neurogenic origin, ostensibly through action on sensory afferents and the release of anti-inflammatory mediators. Given its anti-inflammatory potential, thymulin downregulates the release of inflammatory mediators, such as cytokines and chemokines, upregulates anti-inflammatory factors, such as interleukin (IL)-10, and exerts molecular control via the regulation of transcription factors and mediators. Recent evidence tends to indicate that thymulin can be a therapeutic agent in many inflammatory diseases and in pathological conditions affecting the peripheral and/or the central nervous system.
Epitalon
Epitalon is considered the “fountain of youth” peptide. It is a tetra-peptide, which means that it is composed of four amino acid chains. The peptide is used to regulate the cell cycle during telomerase activity. Telomerase, also called telomere terminal transferase, is an enzyme made of protein and RNA subunits that elongates chromosomes. When telomerase activity is not present (when we age), our cells age. Our telomeres get shorter and begin to die off. If telomerase is activated in our cells, our telomeres lengthen, the cell continues to grow and divide, delaying the aging process. (UT Southwestern Medical Lab) Epitalon was discovered by the Russian scientist Professor Vladimir Khavinson. He researched this peptide of over 35 years in both animal and human clinical trials. The results were astounding. For the first time ever, human clinical trials proved beyond doubt that the substance consisted of powerful life extension and anti-aging possibilities.
Epitalon Peptide therapy can increase human lifespan, delay/prevent age-related diseases, boost energy levels, promote deeper sleep, improve skin health and appearance, and heal deteriorated/injured muscle cells.
Epitalon works in the pineal gland of the brain. Its primary role is to increase the natural production of telomerase, a natural enzyme that helps cells reproduce telomeres, which are the protective parts of our DNA. This allows the replication of our DNA, so the body can grow new cells and rejuvenate old ones. It has shown a 33% increase in telomere length in somatic cells. It has many documented effects on general aging and impacts on the circadian rhythm. It promotes a natural cycle and healthy sleep cycles, it also makes sure that cortisol and other stress hormones are not elevated throughout the day, which can lead to excess abdominal weight gain. It helps regulate levels of melatonin and cortisol. It helps make sure cortisol is elevated in the morning and melatonin is elevated in the evening.